Can brain impermeable BACE1 inhibitors serve as anti-CAA medicine?
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منابع مشابه
Can brain impermeable BACE1 inhibitors serve as anti-CAA medicine?
BACKGROUND Cerebral amyloid angiopathy (CAA) is characterized by the deposition of ß-amyloid peptides (Aß) in and surrounding the wall of microvasculature in the central nervous system, together with parenchymal amyloid plaques collectively referred to as cerebral amyloidosis, which occurs in the brain commonly among the elderly and more frequently in patients with Alzheimer's disease (AD). CAA...
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ژورنال
عنوان ژورنال: BMC Neurology
سال: 2017
ISSN: 1471-2377
DOI: 10.1186/s12883-017-0942-y